abstract：BACKGROUND:Circular RNAs (circRNAs) are emerging noncoding RNAs that are involved in many biological processes and diseases. The expression profile of circRNAs in preterm neonates with bronchopulmonary dysplasia (BPD) remains unresolved. METHODS:In BPD infants, peripheral venous blood was drawn and circRNAs were extra...

journal_title：Journal of clinical laboratory analysis

authors： Mao X,Guo Y,Qiu J,Zhao L,Xu J,Yin J,Lu K,Zhang M,Cheng R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) in recipients is a risk factor for donor stem cell graft failure in haploidentical hematopoietic stem cell transplantation (haplo-HSCT), and the treatment to reduce the levels of DSAs is not unanimous. This study was to analysis the role of ...

journal_title：Journal of clinical laboratory analysis

authors： Zhang R,He Y,Yang D,Jiang E,Ma Q,Pang A,Zhai W,Wei J,Feng S,Han M

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:Sex-determining region Y-box 30 (SOX30) suppresses progression of several cancers, whereas its role in breast cancer is unclear. Therefore, we aimed to determine the correlation of SOX30 with tumor characteristics and prognosis in breast cancer patients. METHODS:The tumor samples of 510 breast cancer patient...

journal_title：Journal of clinical laboratory analysis

authors： Peng H,Luo Y,Wu J,Yin W

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Gastric carcinoma (GC) is a familiar carcinoma and serious threat to human health. We investigated the efficacy and mechanism of circular RNA hsa_circ_0001649 on the growth, migration, and invasion of GC cells. METHODS:microRNA (miR)-20a and hsa_circ_0001649 expression was investigated by RT-qPCR and was ch...

journal_title：Journal of clinical laboratory analysis

authors： Sun H,Wang Q,Yuan G,Quan J,Dong D,Lun Y,Sun B

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:This study aimed at exploring the correlation of microRNA (miR)-497/fibroblast growth factor-23 (FGF-23) axis with major adverse cardiac and cerebral event (MACCE) occurrence in end-stage renal disease (ESRD) patients who underwent continuous ambulatory peritoneal dialysis (CAPD). METHODS:Totally, 360 ESRD p...

journal_title：Journal of clinical laboratory analysis

authors： Liu D,Zhou S,Mao H

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Primary adrenal lymphoma (PAL) is an infrequent malignant disease and there is no consensus classification or specialized treatment for it. However, PAL has been observed to have worse prognosis compared with other extrarenal malignant lymphomas and diffuse large B-cell lymphoma presents as the most common s...

journal_title：Journal of clinical laboratory analysis

authors： Chen Y,He HS,Hu QF,Wang G

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Ischemic stroke is one of the most prominent and serious neurological complications of infective endocarditis (IE). Our study was designed to evaluate the predictive value of higher level of plasma D-dimer on admission for the development of ischemic stroke in patients with IE. METHODS:In this prospective s...

journal_title：Journal of clinical laboratory analysis

authors： Xu N,Fu Y,Wang S,Li S,Cai D

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:In previous research, we found diabetes rather than obesity was an independent risk factor of breast cancer. However, why diabetes could lead to increased risk of breast cancer patients remains elusive. Long non-coding RNAE330013P06 has been shown to be upregulated in diabetes, and long non-coding RNAs gener...

journal_title：Journal of clinical laboratory analysis

authors： Chen R,Shi P,Zhang Y,Wu H,Li X,Yang W,Luo F,JinmingXue,Yao L,Yang J,Wang W,Zhang B,Li P,Miao Y,Wang Q,Tian F

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Accumulated evidences indicate that long non-coding RNAs (lncRNAs) participate in many biological mechanisms. Moreover, it acts as an essential regulator in various human diseases such as gastric cancer (GC). Nevertheless, the comprehensive regulatory roles and clinical significance of most lncRNAs in GC are...

journal_title：Journal of clinical laboratory analysis

authors： Zhu Y,Luo C,Korakkandan AA,Fatma YHA,Tao Y,Yi T,Hu S,Liao Q

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Nucleolar and spindle-associated protein 1 (NUSAP1) has been identified to be strongly implicated in the carcinogenesis of cervical carcinoma, breast cancer, and liver cancer, and shows a high expression level in bladder cancer, indicating that NUSAP1 might be a potent target for cancer treatment. Using bioi...

journal_title：Journal of clinical laboratory analysis

authors： Chen Y,Zhang W,Kadier A,Zhang H,Yao X

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:A-kinase-interacting protein 1 (AKIP1) has been reported as an oncogenetic factor in multiple cancers; however, no study has reported its role in non-small cell lung cancer (NSCLC) yet. This study aimed to evaluate the expression of AKIP1, and its correlation with tumor characteristics as well as prognosis i...

journal_title：Journal of clinical laboratory analysis

authors： Liu Y,Tian J,Qin D,Liu J,Xie Y

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:The pulmonary surfactant especially lipids in amniotic fluid can reflect the development stage of fetal lung maturity (FLM). However, the conventional lecithin/sphingomyelin (L/S) ratio method by thin layer chromatography (TLC) is insufficient and inconvenient for FLM prediction in clinical practice. METHOD...

journal_title：Journal of clinical laboratory analysis

authors： Cao Z,Liu J,Xie X,Zhan S,Song W,Wu S,Sun Z,Dong Y,Tang G,Liu Y,Li L,Shen M,Zhai Y,Zou J,Liu X

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:This present study aimed to investigate the correlation of circular RNA SMARCA5 (circ-SMARCA5) with clinicopathological features and overall survival (OS), and the effect of circ-SMARCA5 on cell proliferation and chemotherapy sensitivity to cisplatin/gemcitabine in intrahepatic cholangiocarcinoma (ICC). METH...

journal_title：Journal of clinical laboratory analysis

authors： Lu Q,Fang T

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Acute coronary syndrome (ACS) is the leading cause of death in developing and developed countries, yet assessing the risk of its development remains challenging. Several lines of evidence indicate that small, dense low-density lipoproteins (sd-LDL) are associated with increased cardiovascular disease risk. W...

journal_title：Journal of clinical laboratory analysis

authors： Wu B,Yu Z,Tong T,Tong X,Yang Y,Tang Y,Ren H,Liao Y,Liao J

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Gastric cancer (GC) is one of the global mortality diseases and has a poor prognosis due to the lack of ideal tumor biomarkers. Circular RNAs (circRNAs) are an abundant kind of endogenous RNAs that recently are found play a crucial role in the cancer occurrence and development. Nevertheless, little is known ...

journal_title：Journal of clinical laboratory analysis

authors： Yu X,Ding H,Yang L,Yu Y,Zhou J,Yan Z,Guo J

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Identification of biomarkers for acute myeloid leukemia (AML) is important for treating this malignancy. Recent studies have reported that microRNAs (miRNAs) are stably detectable in the blood/plasma and can be used as biomarkers for various types of cancer including AML. The aim of this study was to analyze...

journal_title：Journal of clinical laboratory analysis

authors： Yu G,Yin Z,He H,Zheng Z,Chai Y,Xuan L,Lin R,Wang Q,Li J,Xu D

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Recently, several studies have investigated the relationship between Pre-miR-27a rs895819 polymorphism and risk of various cancers. However, the relationship between rs895819 and diffuse large B-cell lymphoma (DLBCL) has not been well known. METHODS:In this study, we conducted a case-control study to explor...

journal_title：Journal of clinical laboratory analysis

authors： Tang W,Xu H,Ma D,Ma R,Wu J,Yu X,Feng J,Liu Q

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Renal failure is a severe complication of symptomatic myeloma, related to higher mortality. Recovery from dialysis dependence can lead to enormous survival benefits. We investigated the effect factors for probability of dialysis independence. METHODS:Retrospective data on 45 newly diagnosed MM (NDMM) patien...

journal_title：Journal of clinical laboratory analysis

authors： Song J,Jiang F,Liu H,Ding K,Ren Y,Li L,Wang G,Shao Z,Fu R

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Early recognition and treatment for severe drug eruption are important in improving clinical outcomes. A few studies have reported laboratory parameters to evaluate the severity of drug eruptions. This study aimed to determine the association between serum ferritin and the severity of drug eruptions. METHOD...

journal_title：Journal of clinical laboratory analysis

authors： Pan Y,Tang S,Zheng S,Li S,Zhu D,Fang H,Qiao J

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:This study aimed to evaluate the association of circular RNA La-related RNA-binding protein 4 (circ-LARP4) with clinical features and prognosis in osteosarcoma patients, and further explore its effect on chemosensitivity in osteosarcoma cells. METHODS:Seventy-two osteosarcoma patients with Enneking stage II...

journal_title：Journal of clinical laboratory analysis

authors： Hu Y,Gu J,Shen H,Shao T,Li S,Wang W,Yu Z

更新日期：2020-02-01 00:00:00

abstract：BACKGROUNDS:Shortening of primary cilia in kidney epithelial cells is associated with kidney injury and involved with the induced level of α-tubulin in urine. Therefore, rapid detection and quantification of α-tubulin in the urine samples could be used to the preliminary diagnosis of kidney injury. METHODS:Cellulose-b...

journal_title：Journal of clinical laboratory analysis

authors： Choi ES,Al Faruque H,Kim JH,Cho JH,Park KM,Kim E

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:MicroRNAs play a vital role in coronary artery disease. Abnormal expression of microRNAs has been found to be associated with the occurrence of CAD. METHODS:We identified significantly differentially expressed microRNAs in plasma between 40 patients with CAD and 10 controls with NCA using RNA sequencing. Th...

journal_title：Journal of clinical laboratory analysis

authors： Zhong Z,Zhong W,Zhang Q,Zhang Q,Yu Z,Wu H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:So far, there has been no tool to estimate activity at diagnosis and predict all-cause mortality in patients with ANCA-associated vasculitis (AAV). Hence, we determined the initial predictors of them in patients with AAV. METHODS:We retrospectively reviewed the medical records of 182 patients with AAV. Seve...

journal_title：Journal of clinical laboratory analysis

authors： Kim MK,Choi H,Kim JY,Song JJ,Park YB,Lee SW

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The aim of this study was to explain the effects of microRNA-132 in renal cell carcinoma by regulating FOXM1 expression. METHODS:Thirty patients with renal cell carcinoma admitted to our hospital were enrolled, and their adjacent normal tissues and cancer tissues were taken. The expression of microRNA-132 w...

journal_title：Journal of clinical laboratory analysis

authors： Yu Y,Lu W,Zhou X,Huang H,Shen S,Guo L

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Contradictory results have been reported previously in the analyses of cross-reactivity among Blomia tropicalis (Blo t), Dermatophagoides pteronyssinus (Der p), and Dermatophagoides farinae (Der f). This study aims to investigate the characteristics of co-sensitization and the IgE cross-reactivity among them...

journal_title：Journal of clinical laboratory analysis

authors： Liu X,Zheng P,Zheng SG,Zhai Y,Zhao X,Chen Y,Cai C,Wu Z,Huang Z,Zou X,Liao C,Sun B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) are a special class of endogenous noncoding RNAs that have numerous biological functions in normal situation and diseases including cancers. However, the clinical significance of circRNAs in gastric cancer (GC) remains largely unknown. Here, we chose two representative circRNAs, hsa_...

journal_title：Journal of clinical laboratory analysis

authors： Lu R,Shao Y,Tao X,Ye G,Xiao B,Guo J

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND:This study aimed to determine whether CD44 polymorphisms were correlated with hepatocellular carcinoma (HCC) and to reveal a new potential target for early prediction, prevention, and diagnosis of HCC. METHOD:This study involved 96 cases with chronic hepatitis B (CHB), 96 cases with hepatitis B virus-relate...

journal_title：Journal of clinical laboratory analysis

authors： Deng Y,Chen ZJ,Lan F,He QT,Chen SY,Du YF,Li S,Qin X

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Low concentration C-reactive protein (CRP) has favorable prognostic significance in patients with cardiovascular risks. METHODS:We compared the wr-CRP method with the hs-CRP method both on Roche Cobas c702 analyzer for the determination of low CRP concentration (<20 mg/L) including 200 patients treated in C...

journal_title：Journal of clinical laboratory analysis

authors： Li R,Xue Y,Wang T,Gong L,Peng P,Xiong P,Dai M,Shao T,Hu Y,Ye X

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:Neurofilaments are the major cytoskeletal components of neurons, and cell injury leads to their release into the surrounding area. The aim of this study was to compare the cerebrospinal fluid (CSF) and serum (S) concentrations of neurofilament light chains (NFLs) and phosphorylated neurofilament heavy chains...

journal_title：Journal of clinical laboratory analysis

authors： Kušnierová P,Zeman D,Hradílek P,Čábal M,Zapletalová O

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Blood gas analysis and blood lactate measurement have important roles in patient management. Point-of-care (POC) testing simplifies and provides rapid blood gas and lactate measurements. This study aimed to compare pH, pCO2 , pO2 , and lactate measurements between a POC device and a benchtop blood gas analyz...

journal_title：Journal of clinical laboratory analysis

authors： Indrasari ND,Wonohutomo JP,Sukartini N

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:The Architect HIV Ag/Ab Combo has excellent performance for HIV screening; however, the false-positive rate (FPR) was high in low HIV prevalence setting. OBJECTIVES:The purpose of this study was to analyze the influence of sample-to-cutoff (s/co) ratios by Architect HIV Ag/Ab Combo with the results of confi...

journal_title：Journal of clinical laboratory analysis

authors： Wang L,Wang JY,Tian XD,Ruan JX,Yu Y,Yan F

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Previous studies suggested that adiponectin (APN) could ameliorate ischemia/reperfusion injury and endothelial dysfunction in patients with acute myocardial infarction. However, the relationship between serum APN level and coronary flow after primary percutaneous coronary intervention (PPCI) in patients with...

journal_title：Journal of clinical laboratory analysis

authors： Liang S,Li H,Shen X,Liu R

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Although recent studies have indicated that gut microbiome dysbiosis was significantly associated with the onset of type 2 diabetes mellitus (T2DM), information on the role of blood microbiome in T2DM development is scarce. METHODS:Fifty incident T2DM cases and 100 matched non-T2DM controls were selected fr...

journal_title：Journal of clinical laboratory analysis

authors： Qiu J,Zhou H,Jing Y,Dong C

更新日期：2019-05-01 00:00:00

abstract：INTRODUCTION:The pro- and anti-inflammatory cytokines play crucial role in the development and functions of placenta. Any changes in these cytokines may be associated with many pregnancy-related disorders like preeclampsia. Therefore, the present study is aimed to study the expression of pro-inflammatory (TNF-α, IL-6) ...

journal_title：Journal of clinical laboratory analysis

authors： Aggarwal R,Jain AK,Mittal P,Kohli M,Jawanjal P,Rath G

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Bone marrow (BM) study plays an important role as initial investigation specimen of lymphoma as well as staging lymphoma. This study aimed to investigate the utility of BM studies for classification of lymphoma and evaluate features of BM involvement by lymphoma over a period of 11 years. METHODS:A total of...

journal_title：Journal of clinical laboratory analysis

authors： Kwoun WJ,Ahn JY,Park PW,Seo YH,Kim KH,Seo JY,Lee HT,Yoo KH

更新日期：2019-05-01 00:00:00

abstract：AIMS:Essential hypertension (EH) is a high prevalence disease facing a public health challenge. People were little known about the genetics of diagnosing the cause of EH. Circular RNAs that have a continuous cycle of covalent closure, without affected by RNA exonuclease, and are more stable and hard to degrade may invo...

journal_title：Journal of clinical laboratory analysis

authors： Bao X,He X,Zheng S,Sun J,Luo Y,Tan R,Zhao J,Zhong F,Zhang L

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Fork head/winged helix transcription factor (Foxp3) plays a pivotal role in regulatory T (Treg) cells. The present study aimed to assess the association of Crohn's disease (CD) with Foxp3 polymorphisms and its colonic expression in Chinese patients. METHODS:The Foxp3 polymorphisms, rs3761547, rs2232365, rs2...

journal_title：Journal of clinical laboratory analysis

authors： Xia S,Zhang D,Zheng S,Wu C,Lin Q,Ying S,Shao X,Jiang Y

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Coronary heart disease (CHD) is primarily caused by atherosclerosis of coronary arteries. It is largely an inflammatory disease of the vascular wall. The inflammation is related to DNA methylation. Angiopoietin-like protein 2 (ANGPTL2) has various functions in several chronic inflammatory diseases. Macrophag...

journal_title：Journal of clinical laboratory analysis

authors： Zhou J,Chen L,Yang X,Huang X,Wang Z,Peng P,Lian J

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Little is known about the involvement of herpes simplex virus (HSV) or Mycobacterium tuberculosis (MTB) as potentially curable causes of central nervous system (CNS) infections in sub-Saharan Africa. OBJECTIVE:In this study, we developed a PCR assay dedicated to simultaneous testing of HSV1/HSV2 and MTB in ...

journal_title：Journal of clinical laboratory analysis

authors： Zida S,Kolia-Diafouka P,Kania D,Sotto A,Foulongne V,Bolloré K,Ouangraoua S,Méda N,Carrère-Kremer S,Van de Perre P,Tuaillon E

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:We aimed to assess the predictive value of long noncoding RNAs antisense noncoding RNA in the INK4 locus (lncRNAs ANRIL) for acute exacerbation of chronic obstructive pulmonary disease (COPD) and evaluate its correlation with inflammatory cytokines as well as the Global Initiative for Chronic Obstructive Lun...

journal_title：Journal of clinical laboratory analysis

authors： Ge J,Geng S,Jiang H

更新日期：2019-02-01 00:00:00